A team led by scientists from the Brazilian University of São Paulo (USP) in São Carlos has found some biologically active compounds in a sea sponge living in the Fernando de Noronha archipelago. These molecules have antibacterial properties – they are able to kill bacteria that have resistance (resistance) to modern antibiotics. The findings of the work are published in the Journal of Natural Products.
A study supported by the public foundation FAPESP has identified antibacterial substances in the sea sponge Agelas dispar, which lives in the Caribbean Sea, using new modern methods of analysis. Three different types of ageliferin had the greatest therapeutic potential. They destroyed resistant bacteria Escherichia coli and Enterococcus faecalis, Staphylococcus aureus, Klebsiella pneumococcus, Acinetobacter baumannii and Pseudomonas aeruginosa. The 13 candidate compounds were also tested on tumor cells from ovarian, lung, colon and breast cancers, but were not shown to be effective. According to scientists, their achievement opens up new horizons for the development of antibacterial drugs.
In May 2022, Rockefeller University employees introduced a new antibiotic, cilagicine, which can destroy even antibiotic-resistant bacteria (Clostridium difficile or methicillin-resistant Staphylococcus aureus).